The Effect of Portulacaoleracea L Consumption and Regular Exercise on Levels of Cathepsin S, Cystatin C and C-Reactive Protein in Diabetic Women

Abstract &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and Objectives: Diabetes induced oxidative stress plays an important role in pathological damage to the heart and liver by increased production of extracellular matrix. It is thought that the use of medicinal plants, particularly Portulaca oleracea. L and regular exercise are effective. The aim of this study was to evaluate the effects of Portulaca oleracea. L consumption along with resistance training on cathepsin S, cystatin C and C-reactive protein (CRP) levels on type 2 diabetes patients. &nbsp;&nbsp;&nbsp;&nbsp; Methods: In this semi-experimental study, 28 female type 2 diabetes patients with a mean age of 52 were randomly devided into 4 groups of control, exercise, supplement and supplement-exercise. Portulaca oleracea. L supplement was cosumed 7.5 g per day. Resistance training program was performed with a rubber band for 8 weeks, 3 days a week for 60 minutes with40-50% intensity, up to a maximum repetition. Blood samples were taken before and 48 hours after the last intervention. &nbsp;&nbsp;&nbsp;&nbsp; Results: After eight weeks, cathepsin S, cystatin C and CRP levels in the supplementation and supplementaion-exercise group were significantly reduced (P<0.05). There were also significant differences between the groups. &nbsp;&nbsp;&nbsp; Conclusion: Portulaca oleracea. L consumption and resistance training have each separate positive impacts on the cathepsin S, cystatin C and CRP levels, but the simultanous effect of Portulaca oleracea. L seed consumption and physical activity can lead to a better efficiency. &nbsp;&nbsp;&nbsp;&nbsp; Keywords: Portulaca oleracea, resistance training, cathepsin S, &nbsp;cystatin C, C-reactive protein, type 2 diabetes mellitus.